Help us caption and translate this video on Amara.org: http://www.amara.org/en/v/B5Eg/
A short video on how benzodiazepines, barbiturates, BZ agonists like zolpidem, and how antagonists like flumazenil work. The focus is on the GABA receptor and an explanation of CNS depression. View the rest of my posted videos below:
(1) Pharmacokinetics Core concepts: http://youtu.be/CMRZqdrkCZw
DRUG ABSORPTION Videos:
(2) Drug Absorption Overview: http://youtu.be/eya9jR3v7i8
(3) Bioavailability: http://youtu.be/rv2Rpdi7OHM
DRUG DISTRIBUTION Videos:
(4) Drug Distribution Overview: http://youtu.be/DH2WGUd7MBs
(5) Volume of Distribution: http://youtu.be/B63sqUfvFQQ
DRUG METABOLISM Videos:
(6) First Pass Metabolism: http://youtu.be/5AB8WkCbz4k
(7) Phase I Metabolism: http://youtu.be/GGLddVpVg9M
(8) Phase II Metabolism: http://youtu.be/iIWAUo05GFE
(9) First Order and Zero Order Kinetics: http://youtu.be/XEotDfKhNTw
(10) Drug Half-life: http://youtu.be/eTqPsqnbwoc
(11) First-order elimination rate constant: http://youtu.be/De9999Jj-5Q
DRUG ELIMINATION / EXCRETION
(12) Drug Clearance: [not yet posted]
(13) Practice problems: [not yet posted]
(13) Dosage Regimens: [not yet posted]
Factors That Affect Drug Metabolism:
(14) Enzyme Induction: http://youtu.be/Dtbkc8F_ff0
(15) Competitive Inhibition Overview: http://youtu.be/iNIxMuHuL3w
(16) Competitive Inhibition of Statins: http://youtu.be/Lt1-mjMFniE
(17) Acetaminophen toxicity (Clinical Correlate): [Not yet posted]
(18) Pharmacogenomics Overview: http://youtu.be/3vZxbX5P9TU
(19) Slow Acetylators - Pharmacogenomics: [not yet posted]
Help us caption & translate this video!
Excellent presentation. However, at 7:39, the speaker says "you get more hypnotic effect with less sedative effect" I think this is a contradiction, since hypnosis is the same thing as sedation. Perhaps the speaker meant anxiolytic effect rather than sedative effect? :)
This was actually so helpful, thank you so much, been trying to understand how GABA is inhibitory & how benzos work for an hour and this explained it all perfectly. i never comment on youtube but thank you for this!
You forgot the best part. After you use Benzos or "Z" drugs for more than two weeks, the GABA receptors down regulate. Then you need to take more of your Benzo or "Z" drug to have the same effect. The longer you use them, the more they down regulate your GABA receptors.
And if you decide you want to stop taking them? It can take months or years for your GABA receptors to up regulate back to normal. Meanwhile, you will be in a special kind of hell while you wait for your GABA recptors to up regulate back to normal.
Benzos are extremely effective, but be very careful. Once you are on them, they can be extremely difficult to get off of for a significant percentage of the population.
He did not say "addictive", he said "additive". Because the benzos and the barbs are not competing for the same spot on the channel, they can both bind at their different spots and their effects can be "added" together.
Nice! And thank you. But of course VESICLES do not traverse across the synaptic cleft, it's the GABA from INSIDE the vesicles, released upon their fusing with the neuronal membrane, which diffuse across.
+Lighto Yagami Voltage gated Ca(2+) ion channels lie at the end of an axon and open when an action potential reaches the presynaptic terminal. This causes the vesicles filled with neurotransmitters (could be GABA, glutamate, glycine, norepinephrine, or countless others) (I believe the vesicles are just made of phospholipids like the cell membrane) to fuse with the cell membrane which releases the neurotransmitters into the synapse to interact with the receptors on the post synaptic neuron.
I just want to add some information as to what @TheAncientScholar has commented about GABA(B) receptor discussion:
-the GIRK or G-protein activated Inwardly Rectifying K+ Channel is composed of G beta & gamma subunits and has a slow response to GABA NT
Thank you for this video..
All Drugs are DANGEROUS. It Is Hell on Earth. To be chemically 'Bound' 'Trapped & Tortured" Beyond Belief. 40 Years of Rape & Abuse. Not being able to get up & go out. Not being able to do anything at all. To See & Hear everyone outside having a good time, each & every day of each & every year, when you are 'Brought to your knees' & forced back to bed, when it is so highly agonisingly tremendously impossible to stay up. For me to GET OFF everything cold Turkey & spend countless years struggling in withdrawals. Then find I am Totally ruined & Destroyed. It is Further Hell. No Compensation. No help. Google: Stephen Bailey Evesham The Facts "It is Nothing But what the drugs have done to Me & You All"
Risk and risk management are in abundant supply. I'm sorry you're going through this. FML too, but I struggle to cope and press on. http://synapticmhz.blogspot.com/2014/06/introduction.html Be the best/normal/etc while you can.
Thank you very much Areo. I searched for this topic to get clear on the mechanism of action of Zolpidem to prepare my board exam to become a pharmacist. Your video is very effective because the diagrams gave me multiple viewpoints of the receptor--from a close up of a receptor, to how it fits in neuronal action. It's comprehensive and organized, and that's why I'll be able to pay it forward by telling my future patients about their Zolpidem! Thanks again and please continue doing what you're doing.
I just wanted to comment on the GABA(B) receptor discussion. GABA(B) receptors are g-protein coupled; however, they are able to open Potassium channels. A special type of Potassium channel known as a g-protein activated inwardly rectifying K+ (Potassium) Channel or GIRK channel will open in response to GABA(B) receptor "activation." Great, informative video. Thank you for posting.
@Areo staffarzadeh - peace bro
My question is, does GABA and Glutamine compete for the same binding site?
If they do - would it decrease its use/processes for muscle recovery and rest?
Thanx in advance
very good and on and off alcohol is something that is well explained in your lecture as involves gaga and so people are surprised with spice breath and un opposed to breath tests as a result of all you had made clear thank you sir from dan ragan
Weight loss programs desperately want as many individuals as possible to to try their new products to demonstrate that they really help people lose weight.
Well I discovered a site that will send free samples to your home, its the best way to get free weight loss products :)
You can get them here bit.ly/12LZ1If?v=pwnnc
I suffer from Idiopathic Hypersomnia (or Major Somnolence Disorder). I have a GABA hypersensitivity that is caused by a chemical in my CSF. The effect is similar to being on a constant IV of benzodiazepines therefore things like caffeine & amphetamines do not reverse the effects of this chemical like flumazenil can. However flumazenil is only in the early stages of being compounded so that we can use it effectively so I'm looking for something else that will work the same way Flumazenil does.
You say that the GABAb receptor lets potassium in? I was under the impression GABAb was metabotropic, and didn't have an ion channel like the ionotropic GABAa. Forgive my ignorance, I'm a total amateur :P
Thousand of alcoholics and addicts are saving their lives with baclofen, a GabaB agonist, all around the world. Desperate people going to desperate measures; there IS no "medical protocol." We are professionally organized, we need you to help us explain why high enough GabaB agonist levels obliterate cravings, therefor, addiction to, substances that bind to GabaA. (Is that what's happening?) Forum is My Way Out . com; RedThread12. If I could contact you directly, I would. You can save lives!!
You sir, have a nice project here. You manage to explain everything perfectly, the slides are good, the pictures are explained and your voice doesn't sound like every other person on youtube explaining interesting stuff (yes we all know what it mostly sounds like... Tandooooori)
I normally don't subscribe to people but you really earned it!
Viagra Plus is a new formulation of world-known medication enhanced with the most active and reliable herbs that give you a new feeling of unlimited potency, over-whelming desire and incomparable endurance. Levitra cheap us pharmacy no prescription