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The GABA receptor | How does it work?

Оценок: 1822 | Просмотров: 313369
Help us caption and translate this video on Amara.org: http://www.amara.org/en/v/B5Eg/ A short video on how benzodiazepines, barbiturates, BZ agonists like zolpidem, and how antagonists like flumazenil work. The focus is on the GABA receptor and an explanation of CNS depression. View the rest of my posted videos below: (1) Pharmacokinetics Core concepts: http://youtu.be/CMRZqdrkCZw ---- DRUG ABSORPTION Videos: (2) Drug Absorption Overview: http://youtu.be/eya9jR3v7i8 (3) Bioavailability: http://youtu.be/rv2Rpdi7OHM --------- DRUG DISTRIBUTION Videos: (4) Drug Distribution Overview: http://youtu.be/DH2WGUd7MBs (5) Volume of Distribution: http://youtu.be/B63sqUfvFQQ ------------------ DRUG METABOLISM Videos: (6) First Pass Metabolism: http://youtu.be/5AB8WkCbz4k (7) Phase I Metabolism: http://youtu.be/GGLddVpVg9M (8) Phase II Metabolism: http://youtu.be/iIWAUo05GFE (9) First Order and Zero Order Kinetics: http://youtu.be/XEotDfKhNTw (10) Drug Half-life: http://youtu.be/eTqPsqnbwoc (11) First-order elimination rate constant: http://youtu.be/De9999Jj-5Q ------------------------------------------ DRUG ELIMINATION / EXCRETION (12) Drug Clearance: [not yet posted] (13) Practice problems: [not yet posted] (13) Dosage Regimens: [not yet posted] --------------------------------------------------------------------- Factors That Affect Drug Metabolism: (14) Enzyme Induction: http://youtu.be/Dtbkc8F_ff0 (15) Competitive Inhibition Overview: http://youtu.be/iNIxMuHuL3w (16) Competitive Inhibition of Statins: http://youtu.be/Lt1-mjMFniE (17) Acetaminophen toxicity (Clinical Correlate): [Not yet posted] (18) Pharmacogenomics Overview: http://youtu.be/3vZxbX5P9TU (19) Slow Acetylators - Pharmacogenomics: [not yet posted] Help us caption & translate this video! http://amara.org/v/B5Eg/
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Текстовые комментарии (134)
fida hasan (1 месяц назад)
camilobjrktr (1 месяц назад)
In spanish there aren't many videos about pharmacology as well explained as this one. Despite the language, i understood everything and clarified my doubts. Thanks!!!
Maxine Murphy (3 месяца назад)
you just explanined to me in ten minutes what my teacher could not make me understand in two months - thanks a lot!
jimsac2000 (7 месяцев назад)
Excellent presentation. However, at 7:39, the speaker says "you get more hypnotic effect with less sedative effect" I think this is a contradiction, since hypnosis is the same thing as sedation. Perhaps the speaker meant anxiolytic effect rather than sedative effect? :)
sonya woo (7 месяцев назад)
hello im a nursing student and this short 9 minute video helped me understand and connect the dots for CNS depressants, receptor binding, GABA, and differences between drugs, so thank you :)
Allegra Brogard (9 месяцев назад)
This was actually so helpful, thank you so much, been trying to understand how GABA is inhibitory & how benzos work for an hour and this explained it all perfectly. i never comment on youtube but thank you for this!
sum guy (10 месяцев назад)
Lost my shit at "that was a silly comment.." LMFAO. Concepts were really well explained too.
Bekalu Azizie (10 месяцев назад)
i wish you had been my instractor in cilinical pharmacy school!!!!! tanks mor!!!!!!!!!!!!!!!
TeaCup (1 год назад)
Is this lamictal?
Francesca G (1 год назад)
Moral of the story. Never ever take a benzodiazepine. These drugs are poison and its easier to come off heroin than a benzo.
James Franko (9 дней назад)
lol, what context are you referring too? If you are referring to Anesthesia, then you don't know what you're talking about!
Jim Bob (1 год назад)
You forgot the best part. After you use Benzos or "Z" drugs for more than two weeks, the GABA receptors down regulate. Then you need to take more of your Benzo or "Z" drug to have the same effect. The longer you use them, the more they down regulate your GABA receptors. And if you decide you want to stop taking them? It can take months or years for your GABA receptors to up regulate back to normal. Meanwhile, you will be in a special kind of hell while you wait for your GABA recptors to up regulate back to normal. Benzos are extremely effective, but be very careful. Once you are on them, they can be extremely difficult to get off of for a significant percentage of the population.
Billy.Cox TX (1 год назад)
excellent video. Thank you !
Albaghdadi Albabily (1 год назад)
ZIPHO MADOLWANA (1 год назад)
I respect this guy. He dope
Tim Ridgeway (1 год назад)
No Cigarete by products. Brotizolam + Etizolam stacked with a touch of vodka!!
Tim Ridgeway (1 год назад)
Brotizolam + Etizolam stacked !
SagaOfEquilibre (1 год назад)
Gaba B is a metabotropic receptor. Is it not?
Sunil Yadav (1 год назад)
SagaOfEquilibre yes
Billy.Cox TX (1 год назад)
great video, Thank you. Subbed!
Nelly Hoffman (1 год назад)
THis is great thanks a lot
Neelam khalil (1 год назад)
which software are you using?
stenloli (1 год назад)
thank you
arjun , (2 года назад)
@6.34 how is that addictive ??
studentquestion (1 год назад)
He did not say "addictive", he said "additive". Because the benzos and the barbs are not competing for the same spot on the channel, they can both bind at their different spots and their effects can be "added" together.
Robert Wofford (1 год назад)
not necessarily addictive but habit forming. your brain can become dependent on the inhibitory effect to sleep, lower your anxiety
mai bich (2 года назад)
Sotiris Chaniotakis (2 года назад)
great video
wella li (2 года назад)
that`s reeeeeeally helped me .. thanks you A LOT
sebbe91 (2 года назад)
Jose P (2 года назад)
Excellent video.
pharmedutainment (2 года назад)
Which software did you use to make this presentation?
Fatima Alkhayrallah (2 года назад)
hahaha "man its crazy how the colours look, hehehe"
Fatima Alkhayrallah (2 года назад)
also, thanks for the video :)
Dan Nichols (2 года назад)
Nice! And thank you. But of course VESICLES do not traverse across the synaptic cleft, it's the GABA from INSIDE the vesicles, released upon their fusing with the neuronal membrane, which diffuse across.
Gabriel (2 года назад)
Joe M (2 года назад)
Excellent presentation! I wish you had been my instructor in Pharm school! Thanks!
LesterAmont (2 года назад)
you are an awesome teacher ty also; the colors duke the colors! (anyone remember that popsicle commercial with the dog? "I'm color blind kid")
Ryan Thomas (2 года назад)
Love this presentation style, thank you for helping me study for my exam!
Sohayyel Sahel (2 года назад)
That was so great and informative, I have an exam two days later and I finally understand sedative-hypnotic drugs thank you
SBCand (2 года назад)
Amaying colors, dude... and completely beside the point, also a great intro to GABA, thanks ;)
Nelly Hoffman (2 года назад)
please someone ...does glutamate also use calcium for vesicles or onkly GABA ????
Chris Redmond (2 года назад)
+Lighto Yagami Voltage gated Ca(2+) ion channels lie at the end of an axon and open when an action potential reaches the presynaptic terminal. This causes the vesicles filled with neurotransmitters (could be GABA, glutamate, glycine, norepinephrine, or countless others) (I believe the vesicles are just made of phospholipids like the cell membrane) to fuse with the cell membrane which releases the neurotransmitters into the synapse to interact with the receptors on the post synaptic neuron.
شمس الدين المعظم (2 года назад)
Brian Klug (2 года назад)
Amazing how great the colors look! ;)
Voice Of Zeus (2 года назад)
Is GABA left-hemipshere dominant? I have read that serotonin is produced primarily in the right hemisphere; does that apply for GABA in the left?
Wafikiri (3 года назад)
The post-synaptic potential is not an action potential but a graded potential. Apart from that, a good explanation.
Jessica Ernst (3 года назад)
Very informative! I like the modern day chalk talk
Giovanna R (3 года назад)
great video! thanks a lot!
Minh Lee (3 года назад)
Raj Tyler (3 года назад)
He has just diluted this topic well done
karimjon4928 (3 года назад)
Thank  You  so  much  !!
Angela Victoria A. Gutierrez (3 года назад)
I just want to add some information as to what @TheAncientScholar has commented about GABA(B) receptor discussion: -the GIRK or G-protein activated Inwardly Rectifying K+ Channel is composed of G beta & gamma subunits and has a slow response to GABA NT Thank you for this video..
dirturtles (3 года назад)
That s helpful! Ps: your voice sounds like adam sandler s :)
SGT Morningwood (3 года назад)
Really like this. Since i am on medication. Using benzodiazepines. 
Jacqueline Gonzalez (3 года назад)
This guy sounds hot lol 
Golu Mahajan (1 год назад)
MeetGrady (3 года назад)
06:11 I think the Barbiturates bind to the Beta-subunit only and not the Beta-Gamma-subunit-connection. Otherwise your 3D picture of the GABAA-channel wouldn't make sense.
reham mj (3 года назад)
Thanx from Iraq 😃
MrTommyknocker (3 года назад)
The GABA receptor is a heteropentamer??
MrTommyknocker (3 года назад)
A GABA receptor and a glutamate receptor is not the same thing??
Sami (3 года назад)
Thank you very much , you made it very easy. I was having a hard time in getting the concept of the Mechanism of action
Yahea AR (3 года назад)
thaaaaaaaaaaaanks a lot really helps
Aceboy (3 года назад)
Areo, you are amazing.  Thanks for the video!!!
Mikey (4 года назад)
I love the effects of heroin, even when your clean for a while you can still feel high off a partial agonist.
TinkerBell052 (4 года назад)
You are amazing! thank you for the great lecture!
Kelvinmelvis Mosby (4 года назад)
liked the explanations, helpful stuff and i want to watch the other videos on GABA  
Stephen Bailey (4 года назад)
All Drugs are DANGEROUS. It Is Hell on Earth. To be chemically 'Bound' 'Trapped & Tortured" Beyond Belief. 40 Years of Rape & Abuse. Not being able to get up & go out. Not being able to do anything at all. To See & Hear everyone outside having a good time, each & every day of each & every year, when you are 'Brought to your knees' & forced back to bed, when it is so highly agonisingly tremendously impossible to stay up.  For me to GET OFF everything cold Turkey & spend countless years struggling in withdrawals. Then find I am Totally ruined & Destroyed. It is Further Hell. No Compensation. No help.  Google: Stephen Bailey Evesham     The Facts "It is Nothing But what the drugs have done to Me & You All"
DystopianUtopia (1 год назад)
This is an educational pharmacology video, not a promotion for drug use. Take your preachy BS somewhere else. Everybody knows benzos are very dangerous if abused.
Scott Edwards (3 года назад)
Risk and risk management are in abundant supply. I'm sorry you're going through this. FML too, but I struggle to cope and press on. http://synapticmhz.blogspot.com/2014/06/introduction.html Be the best/normal/etc while you can.
Rony Arencibia (4 года назад)
Dude, you are a bad ass!!! Thank you very much!!!
Vishal Barnela (4 года назад)
Thank you very much Areo. I searched for this topic to get clear on the mechanism of action of Zolpidem to prepare my board exam to become a pharmacist. Your video is very effective because the diagrams gave me multiple viewpoints of the receptor--from a close up of a receptor, to how it fits in neuronal action. It's comprehensive and organized, and that's why I'll be able to pay it forward by telling my future patients about their Zolpidem! Thanks again and please continue doing what you're doing.
TheAncientScholar (4 года назад)
I just wanted to comment on the GABA(B) receptor discussion.  GABA(B) receptors are g-protein coupled; however, they are able to open Potassium channels. A special type of Potassium channel known as a g-protein activated inwardly rectifying K+ (Potassium) Channel or GIRK channel will open in response to GABA(B) receptor "activation." Great, informative video. Thank you for posting.
Scott Edwards (3 года назад)
+Lorrinda Mills too little GABA can do that. http://synapticmhz.blogspot.com/2015/03/learning-to-write-again.html is one page from my blog.
Lorrinda Mills (3 года назад)
Does an imbalance of these above contribute to rigidity in muscles? does anyone here know?   
Shim GMS (4 года назад)
thanks a lot :) Irani hastin?
Canada0609 (4 года назад)
Man its crazy how good these colors look!
Canada0609 (4 года назад)
+Canada0609 3:26
Canada0609 (4 года назад)
I mean: Man, it's crazy how nice these colors look! Hehe eauhhhhhh
rick mytys (4 года назад)
the problem is if you burn the bz out with overuse they can get damaged
Idan Korenblum (4 года назад)
Hi guys, do anyone know what kind of software/s does he using? (other then the graphic tablet). Thanks.
Larry (4 года назад)
Great tutorial, just one slight correction that I am sure you are aware of but at 8:03 GABA-B receptors are G-protein coupled receptors not ion channels.
Chi Legaspi (4 года назад)
..yes that's correct
John Othic (4 года назад)
Great video! I just had to start taking Lorazepam and its nice to find such a clear description of whats going on.
Fatima Boura (4 года назад)
thank you for your clear and excellent explanation..
Pald Vlad (4 года назад)
can you explain what taurine will do? if this is a like GABA which fixes on GABAa or b? And how glucuronolactone and inositol are acting on GABA and dopamine releaser?
i Masikah (4 года назад)
@Areo staffarzadeh - peace bro My question is, does GABA and Glutamine compete for the same binding site? If they do - would it decrease its use/processes for muscle recovery and rest? Thanx in advance
dansing124 (5 лет назад)
very good and on and off alcohol is something that is well explained in your lecture as involves gaga and so people are surprised with spice breath and un opposed to breath tests as a result of all you had made clear thank you sir from dan ragan
zAlgerian MoDz (5 лет назад)
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Michelle (5 лет назад)
I suffer from Idiopathic Hypersomnia (or Major Somnolence Disorder). I have a GABA hypersensitivity that is caused by a chemical in my CSF. The effect is similar to being on a constant IV of benzodiazepines therefore things like caffeine & amphetamines do not reverse the effects of this chemical like flumazenil can. However flumazenil is only in the early stages of being compounded so that we can use it effectively so I'm looking for something else that will work the same way Flumazenil does.
Tobin Averitt (5 лет назад)
Thank you.
ra080991 (5 лет назад)
thank you so much... :D finally I get it
Michelle Chadwick (5 лет назад)
Do you know of anything else (medication or otherwise) other than Flumazenil that will reverse the effects of Benzo's?
EricLou (5 лет назад)
Omg! I love this!!! You save my seminar!!!
jag1155 (5 лет назад)
thank you so much! I really appreciate it
C Henry (5 лет назад)
GREAT video!! Thank you for the concise explanation.
Paul A (5 лет назад)
Great video, thanks a lot for the explanation. Taken as you've done multiple such videos, it's safe to assume you work as a pharmacologists or somewhere within the sphere?
cptorangutang2 (5 лет назад)
You say that the GABAb receptor lets potassium in? I was under the impression GABAb was metabotropic, and didn't have an ion channel like the ionotropic GABAa. Forgive my ignorance, I'm a total amateur :P
Beth Field (5 лет назад)
Thousand of alcoholics and addicts are saving their lives with baclofen, a GabaB agonist, all around the world. Desperate people going to desperate measures; there IS no "medical protocol." We are professionally organized, we need you to help us explain why high enough GabaB agonist levels obliterate cravings, therefor, addiction to, substances that bind to GabaA. (Is that what's happening?) Forum is My Way Out . com; RedThread12. If I could contact you directly, I would. You can save lives!!
Jenny Eckhardt (5 лет назад)
I recently began taking Baclofen. Life-changing. I would love to see an explanation of how it works. Please consider a more detailed lecture. Your presentations are helpful.
Wandelaarke (5 лет назад)
You sir, have a nice project here. You manage to explain everything perfectly, the slides are good, the pictures are explained and your voice doesn't sound like every other person on youtube explaining interesting stuff (yes we all know what it mostly sounds like... Tandooooori) I normally don't subscribe to people but you really earned it!
Bon Rubi (5 лет назад)
los mejores videos estan en ingles :)
Bon Rubi (5 лет назад)
los mejores videos estan en ingles :)
FiShBReaThMOFO (5 лет назад)
Timeless and invalueable information. Thank you good sir.
Izzati Mazlan (5 лет назад)
wow how u did this video? thinking to do the same so that i able to help others.. by the way, this video is really helpful!
smileyhenke1 (5 лет назад)
good stuff man ;)
djbigjay (5 лет назад)
Absolutely PHENOMINAL! Thanks for that!
sci78 (5 лет назад)
very simpley put and educational thanks
beverleykatherine (5 лет назад)
this was awesome! you rock :)
MIKANtoUsagiNEKO (5 лет назад)
i think he's good.i'm not sleepy at all.*i just learnt about gaba today,so this is kinda to refresh my memory* =)) thank you for uploading.
A. J. Marcano (5 лет назад)
What software are you using to draw?
AIMFILMGROUP (5 лет назад)
Good lecture, you sound like a stoned jazz player though. A bit laid back. But overall well done.
DarklonewolfGG (5 лет назад)
is not a mouse, it's a tablet pc or something like that
joytotheworldtoday (5 лет назад)
wow. thanks, it really makes more sense now. are you in pharmacy school?

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