If alpha 2 receptor activation leads to decreasing the release of neurotransmitters from the synaptic vessels by negative feedback mechanism. then it ultimately leads to decrease in the sympathetic response right. then how can you say the drugs (Alpha 2 receptor agonist) classified under adrenergic agonist. though they are decreasing the adrenergic or sympathetic response by decreasing the neurotransmitter release
Great job, All your videos are great, only if you can put the slides in the description in youtube, or if you can attach it on fb, so we can download it and print it, that would help us so much, also You should allow people to donate to the channel.
Guys, I’m only 14, so give me a break for asking this. But what is catochlomine?! I have this medical book and it mentions it 100000000 times but never explains what it is or what it does, and I can’t find it in this video. Plz help!
Highly intellectual and excellent video. Done very diligently and in a very clear way. Easy to undersand. Perfect to study for Pharmacology exams. Studying from it for todays exam. Thank you so very much for taking your time and making this excellent video.
why does alpha 1 receptor inhibits renin release?in fight or flight response, i believe that one's blood pressure would shoot up due to rise in renin release and also vasoconstriction of the vessels, right?
At interval 5:02 you said that kidney contains a1 receptors which stimulates release of renin but in actual all the tissues to be stimulated have a1 receptors but not heart , JGA in kidney and adipocytes they contain b1 adrenergic receptor ..... b1 receptor in kidney stimulates release of renin not a1.....
no... they found on the both adrenergic & cholinergic post ganglionic neuron. but when it comes to the effector site, it changes. adrenergic neurons have Alpha and beta receptors, while cholinergic neurons have muscarinic receptors
"Specific beta(2)-agonist effects on the pancreatic beta cell result in increased insulin secretion, yet other mechanisms, such as increased glucagon secretion and hepatic effects, cause an overall increase in serum glucose and an apparent decrease in insulin sensitivity." J Allergy Clin Immunol. 2002 Dec;110(6 Suppl):S313-7
I was having a hard time understanding the difference between epinephrine and norepinephrine. It's always been explained to me in a complicated way and it turns out the difference is so simple. Thank you for breaking it sown for me!
You forgot abt beta 2 receptors that they also r present on liver and cause gluconeogenesis and glycogenolysis thus increasing blood glucose level ... and also cause increase in intracellular potassium intake...
Thank you very much from a second semester, nursing student. I know there are certain classes that people dread (pharmacology, anatomy and physiology, medical terminology, microbiology). But for me, if I can visualize the concepts into some sort of story, I'm golden. Thanks for helping me be able to visualize this.
Thank you for this video. So you are saying that out of the drugs that you presented, Dopamine, NE, and E are catecholamine like and have a short half-life, while the rest like ephedrine, phenylephrine, dobutamine, etc are non-catecholamines and thus has longer duration of action?
Why would alpha 1 stimulation cause decreased renin production? How would that be advantageous? It seems as if vasoconstriction would be acting to relieve hypotension, so it would make sense if the other actions of the receptor activation enhanced rather than contradicted this effect. Thanks for the awesome, concise yet informative video!
Since alpha 1 agonist action increases SNS response (BP) there is no incentive for renin to be produced, thus the RASS system is not activated. It's the same as if a person is already hypertensive. Activation of RASS would only exacerbate the hypertension.
I am a second year medical student studying for my boards (6 weeks, eek!) and I want to THANK YOU for creating these videos! Pharm has always been my worst subject in medical school and I am so grateful for how thorough yet straightforward your explanations are. Best of luck with your future endeavors, -Jess
i am a first year medical student and i realise that in the field of illustration this misgonistic view of men soley being depicted is often an issue to be addressed. this comment is to commend you on your usage of a female figure for the purposes of this video at 0.19s during the introduction. !
Viagra Plus is a new formulation of world-known medication enhanced with the most active and reliable herbs that give you a new feeling of unlimited potency, over-whelming desire and incomparable endurance. Levitra cheap us pharmacy no prescription