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How Does Gabapentin Work, What Does Gabapentin Do And Gabapentin Reviews
Knowing drugs like Gabapentin work in the body is important in evaluating the usefulness of new anticonvulsants. It helps doctors and drug manufacturers understand how it can affect different parts of the body. With this, they can adjust the chemistry of the drug to improve its performance or remove unwanted side effects.
Gabapentin is the generic version of Neurontin. It is a drug used to prevent and control seizures. The drug can be taken on its own or as an adjuvant to other anti-seizure medications. Aside from that, adults can also consume it to alleviate neuropathic pain.
Two of its known unverified uses include treatment for migraines and insomnia. However, although not a controlled substance, Gabapentin has also been the subject of substance abuse. Known on the streets as the “gabbies,” some have been taking advantage of this drug’s side effects to feel euphoria.
WHAT IS EPILEPSY AND NEUROPATHIC PAIN?
To fully understand how Gabapentin works, you must first know and understand the diseases it aims to prevent: epilepsy and neuropathic pains.
Epilepsy is a disorder affecting the nervous system. It causes the sufferer to become unconscious suddenly and to have violent and uncontrolled movements in the body. If we think of it regarding electricity, epilepsy is like your body short circuiting.
Now, let’s discuss neuropathic pains. This type of pain happens when the nervous system or nerves undergo an abnormally quick rate of degeneration. Doctors usually link it to other diseases such as herpes, shingles, or even diabetes.
As you can observe, both the diseases Gabapentin treats are problems mainly on the nervous system, giving you an idea of how this drug works.
HOW IS GABAPENTIN PROCESSED BY YOUR BODY?
The body handles Gabapentin in the same way it processes other drugs. Once you take the recommended dosage of Gabapentin, it goes to the stomach where it breaks down into smaller particles.
The components of gabapentin work by being absorbed in your intestines. The blood vessels carry the absorbed Gabapentin along with the other nutrients to the liver. Now, the drug goes through a “screening process.” As it is a foreign object, the liver will do its job and block a certain amount of it.
Once transported into the brain, Gabapentin will stabilize the electrical impulses that fire within the central nervous system. Now, the way neurotransmitters send messages to the brain is now affected.
Gabapentin does that by altering the amount of GABA, a “nerve-calming” agent produced by the body. At the same time, it inhibits the production of glutamate, a “nerve-exciting” agent. Experts blame this neurotransmitter as the reason why epileptic seizures happen.
WHAT ARE ITS COMMON SIDE EFFECTS?
Although quite effective in preventing epileptic seizures, it comes with some side effects that may range from very mild to severe. Some of them happen naturally as a result of how the drug works.
Drowsiness: Knowing already what GABA and its function in your body, it makes sense to feel drowsiness as an effect. It is the reason why some have also used it to cure insomnia. What GABA does is calm the brain, thus causing drowsiness.
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Gabapentin "therapeutic value" is stopping synaptogenesis the formation of new Synapses. That's how it works...
They used to think that the formation of new synapse only happened in the womb and at a very young age so it didn't matter if adults had this class of medications Gabapentin and Lyrica. In 2000 the Noble Prize was for proving that Synaptic regeneration continued. New finding in neuroscience is also discovering more and more how important Synaptic regeneration is for cognitive health and cognitive decline as we age. There is absolutely no long term evidence on the topic concerning Gabapentin and Lyrica. They don't deny it stops Synaptic formation they simply don't do the studies needed to prove the safety of this class of medications. Gabapentin is FDA approved as a adjunct medication for partial complex seizures as a "adjunct" helper medication to a primary medication in that study its states it's only effective for 3 months. That's why it's rarely used for seizures. It can cause seizures as a side effect. It can make absence and myoclonic seizures worse. So it has a very narrow window of usage for seizures. It's also FDA approved for Post Herpatic Neuralgia associated with the Shingles virus. As a adjunct to a antivirus medication. These are the only two FDA approval reasons, everything else is off label. Painful diabetic neuropathy is not FDA approved with Gabapentin like most Doctors use it. It's 38% effective (Cochran review) that does not meet 50% FDA guidelines. So it's useful for diabetic neuropathy but doesn't help everyone. All other off-label percentages go down hill from there. Neurontin, Gabapentin brand name has a Supreme Court RICO Violation for its off label sales and promotion that changed Pharma marketing practices across the board. Dr. Scott Rueben went to prison for falsified clinical trials of Topomax. In that court trial 21 pain medications were found to have falsified information. Gabapentin and Lyrica's false results have not been changed, removed or revisited and still what Doctors use for information.
There are many neurontin suicides law suits because they both have suicides warnings as all AEDs do.
With the changes in neuroscience and updates information on Synaptic plasticity and synaptogenesis and lack of evidence on these medications people should research well and use with caution outside of FDA approval.
It is suggested that gabapentin may block the calcium channel alpha(2)delta (a2d)-1 receptor in the brain. This protein-modulated receptor is involved in excitatory synapse formation. Therefore, the therapeutic effects of gabapentin may be attributed to prevention of new synapse formations. 2the speed at which axons fire, which reduces pain signals.axons fire, which reduces pain signals.
Gabapentin is actually a neuromodulator. It slows down the speed at which axons fire, which reduces pain signals.
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